Duke University Hospital Duke Raleigh Hospital Duke Regional Hospital

Usual Dose & Administration

Usual Adult Dose

250-500 mg PO q12

Adjustment of Dose & Administration

Indication-Specific Adjustment

Indication CrCl (mL/min)
>=30 10-29 <10, IHD
uncomplicated UTI, upper respiratory tract infection, mild-moderate skin infection 250mg q12h 250mg q24h 250mg q48h
Lower respiratory tract infection, complicated UTI 500mg q12h 500mg q24h 500mg q48h

 

Drug-Specific Information

Suspension must be administered with meals.

Cost Index

$ (1-10)

General Notes

  1. Up to date cost information, click here
  2. IV antimicrobials outpatient (OPAT) dosing, click here
  3. Obesity dosing weight recommendations, click here
  4. Helpful drug-drug interaction check website here 
  5. When dosing guidance is provided it is important to note the following:

Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.